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Discontinue paroxetine in any patient who develops seizures. Interactions that can increase your risk of side effects Taking paroxetine with certain drugs raises your risk of side effects. It is most commonly used to treat phobias, aggression, separation anxiety, and compulsive disorders in dogs. Paxil may treat be effective in feline urine marking and compulsive disorders. Paroxetine should not be used in animals with a known allergy paroxetine hypersensitivity to the drug.
This can cause your body to process drugs more slowly. Long-term use may used required for some cases.
Caution is also necessary when using in elderly animals and in those with a history of seizures. Monoamine oxidase inhibitors MAOIs , phenytoin, cimetidine, and L-tryptophan can interact with paroxetine and should not be used in animals undergoing treatment with the drug.
Other drugs with a potential to interact with paroxetine include warfarin, encainide, flecainide, buspirone, tricyclic antidepressants, diazepam, lithium, haloperidol, phenylbutazone, and others. Paroxetine should not be used in animals with a known allergy or hypersensitivity to the drug. Any known or suspected overdose should be reported to a veterinarian right away.
Storage Paroxetine should be stored in a dry, cool place and at room temperature. It should be kept away from heat and direct sunlight and out of the reach of children and animals. Paroxetine should not be stored in the bathroom or above the kitchen sink.
It may break down after exposure to moisture or heat. Administration Paroxetine is available as tablets in strengths of 20 mg and 30 mg. The typical dose of paroxetine in dogs is 0. However, there is substantial evidence from placebo-controlled maintenance trials in adults with MDD that antidepressants delay the recurrence of depression and that depression itself is a risk factor for suicidal thoughts and behaviors. Monitor all antidepressant-treated patients for any indication for clinical worsening and emergence of suicidal thoughts and behaviors, especially during the initial few months of drug therapy, and at times of dosage changes.
Counsel family members or caregivers of patients to monitor for changes in behavior and to alert the healthcare provider. Consider changing the therapeutic regimen, including possibly discontinuing Paroxetine, in patients whose depression is persistently worse, or who are experiencing emergent suicidal thoughts or behaviors. The risk is increased with concomitant use of other serotonergic drugs including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St.
John's Wort and with drugs that impair metabolism of serotonin, i. Serotonin syndrome can also occur when these drugs are used alone. Serotonin syndrome signs and symptoms may include mental status changes e. In addition, do not initiate Paroxetine in a patient being treated with MAOIs such as linezolid or intravenous methylene blue. No reports involved the administration of methylene blue by other routes such as oral tablets or local tissue injection.
If it is necessary to initiate treatment with an MAOI such as linezolid or intravenous methylene blue in a patient taking Paroxetine, discontinue Paroxetine before initiating treatment with the MAOI [see Contraindications 4 , Drug Interactions 7.
Monitor all patients taking Paroxetine for the emergence of serotonin syndrome. Discontinue treatment with Paroxetine and any concomitant serotonergic agents immediately if the above symptoms occur, and initiate supportive symptomatic treatment. If concomitant use of Paroxetine with other serotonergic drugs is clinically warranted, inform patients of the increased risk for serotonin syndrome and monitor for symptoms.
Since thioridazine and pimozide given alone produce prolongation of the QTc interval and increase the risk of serious ventricular arrhythmias, the use of Paroxetine is contraindicated in combination with thioridazine and pimozide [see Contraindications 4 , Drug Interactions 7 , Clinical Pharmacology Epidemiological studies have shown that infants exposed to paroxetine in the first trimester of pregnancy have an increased risk of cardiovascular malformations. If Paroxetine is used during pregnancy, or if the patient becomes pregnant while taking Paroxetine, the patient should be apprised of the potential hazard to the fetus [see Use in Specific Populations 8.
The duration of the treatment depends on many factors. Severity of dog anxiety influences this period. The response to the drug is yet another variable. If the veterinarian does not recommend the termination of the treatment, then the prescription needs to be completed, even if the symptoms are improved.
Precautions and Adverse Reactions Paroxetine is available only with a prescription, so it is mandatory to visit a veterinarian in order to get it. Provided that the dosage recommended by the veterinarian is respected, the probability that the dog will experience any side effects is rather low.
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Jun 06, · What is fluoxetine? Fluoxetine (brand names: Prozac®, Reconcile®, Sarafem®) is an SSRI antidepressant used to treat a variety of behavioral disorders in dogs and cats. The FDA approved form for dogs is labeled to treat separation anxiety.
Its use in cats, dogs, and birds to treat certain behavioral conditions is 'off label' or 'extra label'.
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